Systemic regulation of retinal medium-chain fatty acid oxidation repletes TCA cycle flux in oxygen-induced retinopathy

Abstract Activation of anaplerosis takes away glutamine from the biosynthetic pathways to the energy-producing TCA cycle.Especially, induction of hyperoxia driven anaplerosis in neurovascular tissues such as the retina during early stages of development could deplete biosynthetic precursors from newly proliferating endothelial cells impeding physio

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Socio-constructivist pedagogy in physical and virtual spaces: the impacts and opportunities on dialogic learning in creative disciplines

The process and outcomes of the design studio are extensively communicated through visual means.However, notwithstanding such tangible manifestations of learning, design education is characterised by dialogue, the discussions in studio between tutors and students and between the students themselves.As such, it aligns strongly with socio-constructiv

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